CYCLOBENZAPRINE HCL
- Product Name
- CYCLOBENZAPRINE HCL
- CAS No.
- 303-53-7
- Chemical Name
- CYCLOBENZAPRINE HCL
- Synonyms
- CYCLOBENZAPRINE;mk130;MK-130;RP-9715;9715r.p.;ro4-1577;Ro-4-1577;Proeptatriene;proheptatrien;Proheptatriene
- CBNumber
- CB1116384
- Molecular Formula
- C20H21N
- Formula Weight
- 275.39
- MOL File
- 303-53-7.mol
CYCLOBENZAPRINE HCL Property
- Boiling point:
- bp1 175-180°
- Density
- 0.9504 (rough estimate)
- refractive index
- 1.7500 (estimate)
- pka
- pKa 8.47 (Uncertain)
- BCS Class
- 1
- NIST Chemistry Reference
- Cyclobenzaprine(303-53-7)
Safety
- Hazardous Substances Data
- 303-53-7(Hazardous Substances Data)
- Toxicity
- LD50 oral in mouse: 250mg/kg
N-Bromosuccinimide Price
- Product number
- KIT7835
- Product name
- Cyclobenzaprine(1.0mg/mLinMethanol)
- Packaging
- 5x1ml
- Price
- $105
- Updated
- 2021/12/16
- Product number
- API0009177
- Product name
- CYCLOBENZAPRINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.28
- Updated
- 2021/12/16
- Product number
- MT-49581
- Product name
- Cyclobenzaprine
- Purity
- 98%
- Packaging
- 0.05g
- Price
- $410
- Updated
- 2021/12/16
CYCLOBENZAPRINE HCL Chemical Properties,Usage,Production
Description
Cyclobenzaprine is structurally similar to tricyclic antidepressants. It acts at the brain stem level.
Originator
Flexeril,Merck Sharp andDohme,US,1977
Uses
It is used as an adjuvant agent for relieving muscle spasms associated with severe diseased conditions of the muscle. A synonym of this drug is flexeril.
Uses
Relaxant (muscle).
Definition
ChEBI: 5-Methylidene-5H-dibenzo[a,d]cycloheptene in which one of the hydrogens of the methylidene group is substituted by a 2-(dimethylamino)ethyl group. A centrally acting skeletal muscle relaxant, it is used as its h drochloride salt in the symptomatic treatment of painful muscle spasm.
Manufacturing Process
In an initial step, dibenzo [a,d]cyclohepten-5-one is reacted with the Grignardreagent of 3-dimethylaminopropyl chloride and hydrolyzed to give 5-(3-dimethylaminopropyl)-dibenzo[a,d][1,4]cycloheptatriene-5-ol. Then 13 g ofthat material, 40 ml of hydrochloric acid, and 135 ml of glacial acetic acid isrefluxed for 3? hours. The solution is then evaporated to dryness in vacuoand added to ice water which is then rendered basic by addition of ammoniumhydroxide solution. Extraction of the basic solution with chloroform andremoval of the solvent from the dried chloroform extracts yields the crudeproduct which when distilled in vacuo yields essentially pure 5-(3-dimethylaminopropylidene)-dibenzo[a,d][1,4]cycloheptatriene, BP 173°C to177°C at 1.0 mm.
brand name
Flexeril (McNeil).
Therapeutic Function
Muscle relaxant
Synthesis
Cyclobenzaprine, N,N-dimethyl-3-(dibenzo[a,d]cyclohepten-5-ylidene) propylamine (15.3.9), is synthesized by reacting 5H-dibenzo[a,d]cyclohepten-5-one with 3-dimethylaminopropylmagnesium chloride and subsequent dehydration of the resulting carbinol (15.3.8) in acidic conditions into cyclobenzaprine (15.3.9).
CYCLOBENZAPRINE HCL Preparation Products And Raw materials
Raw materials
Preparation Products
CYCLOBENZAPRINE HCL Suppliers
View Lastest Price from CYCLOBENZAPRINE HCL manufacturers
- Product
- CYCLOBENZAPRINE HCL 303-53-7
- Price
- US $15.00/KG
- Min. Order
- 1KG
- Purity
- 99.9%
- Supply Ability
- 500MT/month
- Release date
- 2021-12-20
- Product
- CYCLOBENZAPRINE HCL 303-53-7
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-09